Title : Hypopituitaric patients with corticotropin insufficiency show marked impairment of the cortisol response to ACTH (1-24) independently of the duration of the disease.

Pub. Date : 2003 Jan

PMID : 12602534






2 Functional Relationships(s)
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1 The DHEA responses to ACTH in HYPOPIT were dose-independent and markedly lower than in NS (p < 0.0001). Dehydroepiandrosterone proopiomelanocortin Homo sapiens
2 The impaired F and DHEA response to ACTH is also independent of the dose, suggesting the existence of relatively enhanced sensitivity of the fasciculata and reticularis adrenal zone to ACTH but meantime remarkable impairment of the adrenal function due to corticotrophin deficiency. Dehydroepiandrosterone proopiomelanocortin Homo sapiens