Title : Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8.

Pub. Date : 2003 May 2

PMID : 12601003






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here we show that expression of two target genes of LXRalpha, the ATP-binding cassette (ABC) transporters Abcg5 and Abcg8, is required for both the increase in sterol excretion and the decrease in fractional cholesterol absorption associated with LXR agonist treatment. Sterols ATP binding cassette subfamily G member 5 Mus musculus
2 Thus Abcg5 and Abcg8 are required for LXR agonist-associated changes in dietary and biliary sterol trafficking. Sterols ATP binding cassette subfamily G member 5 Mus musculus