Pub. Date : 2003 Feb
PMID : 12598410
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of intestinal dipeptide transport by the neuropeptide VIP is an anti-absorptive effect via the VPAC1 receptor in a human enterocyte-like cell line (Caco-2). | Dipeptides | vasoactive intestinal peptide | Homo sapiens |
| 2 | The ability of the anti-absorptive enteric neuropeptide VIP (vasoactive intestinal peptide) to modulate dipeptide uptake was determined using human intestinal (Caco-2) epithelial cell monolayers. | Dipeptides | vasoactive intestinal peptide | Homo sapiens |
| 3 | The ability of the anti-absorptive enteric neuropeptide VIP (vasoactive intestinal peptide) to modulate dipeptide uptake was determined using human intestinal (Caco-2) epithelial cell monolayers. | Dipeptides | vasoactive intestinal peptide | Homo sapiens |
| 4 | Experiments with BCECF [2",7"-bis(2-carboxyethyl)-5(6)-carboxyfluorescein]-loaded Caco-2 cells demonstrate that VIP reduces the NHE3-dependent recovery of intracellular pH (pH(i)) after dipeptide-induced acidification. | Dipeptides | vasoactive intestinal peptide | Homo sapiens |
| 5 | VIP has no effect on Gly-Sar uptake in the presence of S1611 suggesting that VIP and S1611 both modulate dipeptide uptake via the same mechanism. | Dipeptides | vasoactive intestinal peptide | Homo sapiens |
| 6 | These observations demonstrate that VIP (and PACAP) modulate activity of the H(+)/dipeptide transporter hPepT1 in a Na(+)-dependent manner consistent with the modulation being indirect through inhibition of NHE3. | Dipeptides | vasoactive intestinal peptide | Homo sapiens |