Title : Suppression of beta-casein gene expression by inhibition of protein synthesis in mouse mammary epithelial cells is associated with stimulation of NF-kappaB activity and blockage of prolactin-Stat5 signaling.

Pub. Date : 2003 Feb

PMID : 12596040






1 Functional Relationships(s)
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1 Inhibition of protein synthesis was associated with NF-kappaB binding at a site immediately 3" to the Stat5-binding site at position 97-89 of the beta-casein promoter, suppression of Stat5 DNA-binding activity, and inhibition of Stat5 tyrosine phosphorylation. Tyrosine signal transducer and activator of transcription 5A Mus musculus