Title : PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway.

Pub. Date : 2003 Mar

PMID : 12595494






1 Functional Relationships(s)
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1 Taken together with previous data, it appears that, in addition to increasing lipid uptake, inflammatory cytokines promote intracellular lipid accumulation by inhibiting cholesterol efflux through the PPAR-LXRalpha-ABCA1 pathway. Cholesterol nuclear receptor subfamily 1 group H member 3 Homo sapiens