Title : Concomitant recruitment of ERK1/2 and p38 MAPK signalling pathway is required for activation of cytoplasmic phospholipase A2 via ATP in articular chondrocytes.

Pub. Date : 2003 Apr 18

PMID : 12591927






1 Functional Relationships(s)
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1 ATP significantly increased arachidonic acid production, which involved the activation of the 85-kDa cytosolic phospholipase A(2) (cPLA(2)) but not a secreted form of PLA(2), as demonstrated by various PLA(2) inhibitors and translocation experiments. Arachidonic Acid cytosolic phospholipase A2 Oryctolagus cuniculus