Title : Evidence for an intrarenal beta receptor in control of renin release.

Pub. Date : 1976 Feb

PMID : 1259022






3 Functional Relationships(s)
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1 Infusion of isoproterenol intravenously in normal dogs at rates of 0.10 or 0.018 mug/min per kg body wt increased renin secretion; at the lower infusion rate arterial pressure (AP) and renal blood flow (RBF) were unchanged. Isoproterenol renin Canis lupus familiaris
2 Isoproterenol was also infused into the renal artery in normal dogs at 0.10 mug/min per kg; renin secretion increased in association with an increase in RBF but AP was unchanged. Isoproterenol renin Canis lupus familiaris
3 Plasma K concentration was consistently decreased in all three of the above experiments and because hypokalemia is known to increase renin release isoproterenol was not infused intrarenally at the lower rate; the decrease in plasma K level precluded relating the entire response in renin release to isoproterenol. Isoproterenol renin Canis lupus familiaris