Title : Transcriptional activation of the human inducible nitric-oxide synthase promoter by Kruppel-like factor 6.

Pub. Date : 2003 Apr 25

PMID : 12590140






2 Functional Relationships(s)
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1 The binding of KLF6 to the iNOS promoter was significantly increased in Jurkat cells, primary T lymphocytes, and COS-7 cells subjected to NaCN-induced hypoxia, heat shock, serum starvation, and phorbol 12-myristate 13-acetate/ ionophore stimulation. Sodium Cyanide Kruppel like factor 6 Homo sapiens
2 Furthermore, in KLF6-transfected and NaCN-treated COS-7 cells, there was a 3-4-fold increase in the expression of the endogenous iNOS mRNA and protein that correlated with increased production of nitric oxide. Sodium Cyanide Kruppel like factor 6 Homo sapiens