Title : Conversion of Ser to Thr residues at the sperm combining-site of mZP3 does not affect sperm receptor activity.

Pub. Date : 2003 Feb 21

PMID : 12589785






3 Functional Relationships(s)
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1 Sperm recognize and bind to O-linked oligosaccharides attached to Ser-332 and Ser-334 at the sperm combining-site of mouse ZP3 (mZP3). o-linked oligosaccharides zona pellucida glycoprotein 3 Mus musculus
2 Sperm recognize and bind to O-linked oligosaccharides attached to Ser-332 and Ser-334 at the sperm combining-site of mouse ZP3 (mZP3). o-linked oligosaccharides zona pellucida glycoprotein 3 Mus musculus
3 Results of these experiments suggest that Thr residues can replace the two evolutionarily conserved Ser residues as acceptors for essential O-linked oligosaccharides at the sperm combining-site of mZP3 without affecting the glycoprotein"s sperm receptor activity. o-linked oligosaccharides zona pellucida glycoprotein 3 Mus musculus