Pub. Date : 2003 Feb
PMID : 12584176
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac. | Sulindac | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 2 | beta-catenin and beta-catenin/Tcf-4 regulated proteins Cyclin D(1) and c-Jun were readily detected in polyps, but markedly reduced in normal-looking intestines of mice treated with both tea and sulindac. | Sulindac | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 3 | beta-catenin and beta-catenin/Tcf-4 regulated proteins Cyclin D(1) and c-Jun were readily detected in polyps, but markedly reduced in normal-looking intestines of mice treated with both tea and sulindac. | Sulindac | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 4 | This research provides evidence that teas, particularly when administered in combination with sulindac, are highly effective at inhibiting intestinal neoplasia in male Apc(min) mice via direct or indirect effects on the beta-catenin/APC pathway. | Sulindac | catenin (cadherin associated protein), beta 1 | Mus musculus |