Title : ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation.

Pub. Date : 2003 Feb 15

PMID : 12581736






3 Functional Relationships(s)
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1 The dominant negative form of FADD and z-VAD-fmk inhibited caspase-8, caspase-9, Bid processing, cytochrome c release, and DNA fragmentation induced by ER stress, suggesting that caspase-8 and caspase-9 are the main caspases involved in ER stress-mediated apoptosis of P19-36/12 (-) cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone caspase 8 Mus musculus
2 The dominant negative form of FADD and z-VAD-fmk inhibited caspase-8, caspase-9, Bid processing, cytochrome c release, and DNA fragmentation induced by ER stress, suggesting that caspase-8 and caspase-9 are the main caspases involved in ER stress-mediated apoptosis of P19-36/12 (-) cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone caspase 8 Mus musculus
3 The dominant negative form of FADD and z-VAD-fmk inhibited caspase-8, caspase-9, Bid processing, cytochrome c release, and DNA fragmentation induced by ER stress, suggesting that caspase-8 and caspase-9 are the main caspases involved in ER stress-mediated apoptosis of P19-36/12 (-) cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone caspase 8 Mus musculus