Pub. Date : 2002 Jun 28
PMID : 12575320
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Effect of nicotine on the secretion of TNF of human peripheral blood mononuclear cells in vitro]. | Nicotine | tumor necrosis factor | Homo sapiens |
| 2 | OBJECTIVE: To observe the effect of nicotine on the secretion of TNF of human peripheral blood mononuclear cells (PBMC) in vitro, and explore the possible mechanism of the high level of TNF caused by smoking. | Nicotine | tumor necrosis factor | Homo sapiens |
| 3 | When the concentrations of nicotine were 50 ng.ml-1 and 500 ng.ml-1, the level of TNF increased significantly in non-smokers (P < 0.05, P < 0.01). | Nicotine | tumor necrosis factor | Homo sapiens |
| 4 | In smokers, the level of TNF significantly increased when the concentration of nicotine was 50 ng.ml-1; however, the level of TNF significantly decreased (P < 0.05), and the proliferation of PBMCs was inhibited when the concentration of nicotine was 500 ng.ml-1 (P < 0.05, P < 0.05). | Nicotine | tumor necrosis factor | Homo sapiens |
| 5 | In smokers, the level of TNF significantly increased when the concentration of nicotine was 50 ng.ml-1; however, the level of TNF significantly decreased (P < 0.05), and the proliferation of PBMCs was inhibited when the concentration of nicotine was 500 ng.ml-1 (P < 0.05, P < 0.05). | Nicotine | tumor necrosis factor | Homo sapiens |
| 6 | In smokers, the level of TNF significantly increased when the concentration of nicotine was 50 ng.ml-1; however, the level of TNF significantly decreased (P < 0.05), and the proliferation of PBMCs was inhibited when the concentration of nicotine was 500 ng.ml-1 (P < 0.05, P < 0.05). | Nicotine | tumor necrosis factor | Homo sapiens |
| 7 | CONCLUSION: Nicotine can induce PBMCs to secrete more TNF, and the magnitude of the effect is strongly related to the dosage of nicotine, but a great dose of nicotine will inhibit the production of TNF. | Nicotine | tumor necrosis factor | Homo sapiens |
| 8 | CONCLUSION: Nicotine can induce PBMCs to secrete more TNF, and the magnitude of the effect is strongly related to the dosage of nicotine, but a great dose of nicotine will inhibit the production of TNF. | Nicotine | tumor necrosis factor | Homo sapiens |
| 9 | CONCLUSION: Nicotine can induce PBMCs to secrete more TNF, and the magnitude of the effect is strongly related to the dosage of nicotine, but a great dose of nicotine will inhibit the production of TNF. | Nicotine | tumor necrosis factor | Homo sapiens |
| 10 | CONCLUSION: Nicotine can induce PBMCs to secrete more TNF, and the magnitude of the effect is strongly related to the dosage of nicotine, but a great dose of nicotine will inhibit the production of TNF. | Nicotine | tumor necrosis factor | Homo sapiens |
| 11 | CONCLUSION: Nicotine can induce PBMCs to secrete more TNF, and the magnitude of the effect is strongly related to the dosage of nicotine, but a great dose of nicotine will inhibit the production of TNF. | Nicotine | tumor necrosis factor | Homo sapiens |
| 12 | CONCLUSION: Nicotine can induce PBMCs to secrete more TNF, and the magnitude of the effect is strongly related to the dosage of nicotine, but a great dose of nicotine will inhibit the production of TNF. | Nicotine | tumor necrosis factor | Homo sapiens |