Pub. Date : 2003 Feb
PMID : 12574447
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Extracellular glycine near NMDA-R is regulated effectively by a glial glycine transporter (GlyT1). | Glycine | solute carrier family 6 member 9 | Rattus norvegicus |
| 2 | These data suggest that direct GlyB site stimulation by D-serine, or blockade of GLYT1 to elevate endogenous glycine to act on unsaturated GlyB sites on NMDA-Rs, potentiated NMDA-R-mediated firing responses in rat PFC. | Glycine | solute carrier family 6 member 9 | Rattus norvegicus |
| 3 | Hence, blockade of GlyT1 to elevate glycine near the NMDA-R may activate hypofunctional NMDA-R, which has been implicated to play a critical role in the pathophysiology of schizophrenia. | Glycine | solute carrier family 6 member 9 | Rattus norvegicus |