Title : Preclinical and clinical studies with combinations of pemetrexed and gemcitabine.

Pub. Date : 2002 Dec

PMID : 12571808






1 Functional Relationships(s)
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1 The novel antimetabolite pemetrexed inhibits the folate-dependent enzymes thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase. Pemetrexed dihydrofolate reductase Homo sapiens