Title : Martentoxin, a novel K+-channel-blocking peptide: purification, cDNA and genomic cloning, and electrophysiological and pharmacological characterization.

Pub. Date : 2003 Jan

PMID : 12558995






1 Functional Relationships(s)
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1 The patch-clamp recording found that martentoxin at the applied dose of 100 nm could strongly block large-conductance Ca2+-activated K+ (BKCa) currents in adrenal medulla chromaffin cells, and BKCa currents blocked by martentoxin could be fully recovered within 30 seconds after washing, which is at least 10 times faster than recovery after charybdotoxin. Charybdotoxin potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus