Title : The improved survival of hematopoietic cells cultured with a fusion protein of insulin-like growth factor II (IGF-II) and interleukin 3 (IL-3) is associated with increases in Bcl-xL and phosphatidylinositol-3 kinase activity.

Pub. Date : 2003 Feb

PMID : 12554807






1 Functional Relationships(s)
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1 The PI-3K inhibitor LY294002 specifically inhibited cell survival in the presence of the chimera, suggesting a key role of this enzyme in the potentiation of survival caused by the linkage of IGF and IL-3. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one interleukin 3 Homo sapiens