Title : The rational development of capecitabine from the laboratory to the clinic.

Pub. Date : 2002 Nov-Dec

PMID : 12552961






1 Functional Relationships(s)
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1 Preclinical studies provided evidence of preferential conversion of inactive 5"-DFUR to active 5-FU in solid tumours due to the relative overexpression of the final anabolising enzyme, thymidine phosphorylase (TP), in neoplastic tissues more than in normal counterparts. Fluorouracil thymidine phosphorylase Homo sapiens