Pub. Date : 2002 Nov-Dec
PMID : 12547239
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1. | Iron | solute carrier family 11 member 2 | Homo sapiens |
| 2 | Identification of divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) has improved our understanding of iron transport across the intestinal epithelium. | Iron | solute carrier family 11 member 2 | Homo sapiens |
| 3 | Identification of divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) has improved our understanding of iron transport across the intestinal epithelium. | Iron | solute carrier family 11 member 2 | Homo sapiens |
| 4 | Although DMT1 and FPN1 mRNA bear an iron responsive element (IRE) within its untranslated regions which should cause susceptibility to iron mediated posttranscriptional regulation the latter has not been shown so far. | Iron | solute carrier family 11 member 2 | Homo sapiens |
| 5 | Although DMT1 and FPN1 mRNA bear an iron responsive element (IRE) within its untranslated regions which should cause susceptibility to iron mediated posttranscriptional regulation the latter has not been shown so far. | Iron | solute carrier family 11 member 2 | Homo sapiens |
| 6 | The effects of iron perturbations on DMT1 and FPN1 expression were investigated in CaCo2 cells and in primary tissue cultures of human duodenal biopsies by means of Northern Blot, Western Blot, RNA-bandshift and Nuclear Run off analysis. | Iron | solute carrier family 11 member 2 | Homo sapiens |
| 7 | Nuclear run-off analysis then demonstrated that the effects of iron and desferrioxamine on DMT1 and FPN1 mRNA expression are rather due to modulation of transcription of these genes. | Iron | solute carrier family 11 member 2 | Homo sapiens |
| 8 | Our results demonstrate that iron unidirectionally regulates the expression of the two ferrous ion transporters DMT1 and FPN1 by affecting their transcription. | Iron | solute carrier family 11 member 2 | Homo sapiens |