Pub. Date : 2002 Nov-Dec
PMID : 12547230
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Iron regulatory proteins (IRP1 and IRP2) control the synthesis of transferrin receptors (TfR) and ferritin by binding to iron-responsive elements (IREs) that are located in the 3" untranslated region (UTR) and the 5" UTR of their respective mRNAs. | Iron | aconitase 1 | Mus musculus |
| 2 | ), a redox species of nitric oxide that interacts primarily with iron, can activate IRP1 RNA-binding activity resulting in an increase in TfR mRNA levels and a decrease in ferritin synthesis. | Iron | aconitase 1 | Mus musculus |