Pub. Date : 2003 Jan
PMID : 12538508
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we show that transfection of ER-positive, HER2 gene-amplified BT-74 cells with an expression vector encoding dominant-negative (K179M) Akt1 partially restored the ability of tamoxifen to inhibit estradiol-stimulated ER reporter activity. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Infection of MCF-7 cells with an adenovirus encoding myristoylated, constitutively active Akt induced ER reporter activity in the absence of estradiol and resulted in tamoxifen resistance of these cells in culture. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |