Title : Androgen-mediated induction of the kidney arachidonate hydroxylases is associated with the development of hypertension.

Pub. Date : 2003 Apr

PMID : 12531784






1 Functional Relationships(s)
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1 Dissected renal microvessels, the target tissue for most of the prohypertensive actions of 20-HETE, show an androgen-dependent upregulation of vascular CYP 4A8 mRNA and a fourfold increase in 20-HETE synthase activity. 20-hydroxy-5,8,11,14-eicosatetraenoic acid cytochrome P450, family 4, subfamily a, polypeptide 8 Rattus norvegicus