Pub. Date : 2003 Jan
PMID : 12529415
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interleukin-1beta induces glycosaminoglycan synthesis via the prostaglandin E2 pathway in cultured human cervical fibroblasts. | Glycosaminoglycans | interleukin 1 beta | Homo sapiens |
| 2 | The aim of this study was to identify, in cultured human cervical fibroblasts, the mechanisms by which interleukin (IL)-1beta induces the synthesis of glycosaminoglycans (GAG) and to explore the putative role of prostaglandin E(2) (PGE(2)) in this process. | Glycosaminoglycans | interleukin 1 beta | Homo sapiens |
| 3 | The aim of this study was to identify, in cultured human cervical fibroblasts, the mechanisms by which interleukin (IL)-1beta induces the synthesis of glycosaminoglycans (GAG) and to explore the putative role of prostaglandin E(2) (PGE(2)) in this process. | Glycosaminoglycans | interleukin 1 beta | Homo sapiens |
| 4 | Exposure of the cells for 24 h to IL-1beta induced a significant (P < 0.05) dose-dependent increase in GAG synthesis. | Glycosaminoglycans | interleukin 1 beta | Homo sapiens |
| 5 | AH23848, the selective EP(4) receptor antagonist, completely abolished IL-1beta-induced GAG synthesis, whereas AH6809, an EP(2) receptor antagonist, had no effect on the stimulatory effects of IL-1beta. | Glycosaminoglycans | interleukin 1 beta | Homo sapiens |
| 6 | In conclusion, these findings indicate that IL-1beta not only induced GAG synthesis by increasing COX-2 protein expression and the subsequent PGE(2) production but also enhanced the responsiveness of cervical fibroblasts to PGE(2) by selectively up-regulating EP(4) receptor mRNA expression. | Glycosaminoglycans | interleukin 1 beta | Homo sapiens |