Title : Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21(waf1/cip1).

Pub. Date : 2003 Jan 9

PMID : 12527914






2 Functional Relationships(s)
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Protein Name
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1 Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21(waf1/cip1). Sulfhydryl Compounds tumor protein p53 Homo sapiens
2 Thiol alkylation via inducing the expression of p21(waf1/cip1) in a STAT1- and p53-dependent manner antagonized the downregulation of this cell cycle inhibitory molecule by PDGF-BB. Sulfhydryl Compounds tumor protein p53 Homo sapiens