Pub. Date : 2003 Jan 9
PMID : 12527914
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21(waf1/cip1). | Sulfhydryl Compounds | tumor protein p53 | Homo sapiens |
2 | Thiol alkylation via inducing the expression of p21(waf1/cip1) in a STAT1- and p53-dependent manner antagonized the downregulation of this cell cycle inhibitory molecule by PDGF-BB. | Sulfhydryl Compounds | tumor protein p53 | Homo sapiens |