Title : Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21(waf1/cip1).

Pub. Date : 2003 Jan 9

PMID : 12527914






2 Functional Relationships(s)
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Protein Name
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1 Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21(waf1/cip1). Sulfhydryl Compounds caspase 1 Homo sapiens
2 The inhibition of AP-1 and activation of STATs, particularly STAT1, by thiol alkylation correlated with increased production of active caspase 1 and apoptosis in VSMC. Sulfhydryl Compounds caspase 1 Homo sapiens