Pub. Date : 2003 Feb
PMID : 12524540
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have previously shown that ASPP1 and ASPP2 are specific activators of p53; one mechanism by which wild-type p53 is tolerated in human breast carcinomas is through loss of ASPP activity. | aspp | tumor protein p53 | Homo sapiens |
| 2 | We have previously shown that ASPP1 and ASPP2 are specific activators of p53; one mechanism by which wild-type p53 is tolerated in human breast carcinomas is through loss of ASPP activity. | aspp | tumor protein p53 | Homo sapiens |
| 3 | Hence, an inhibitory form of ASPP resembling 53BP2 could allow cells to bypass the tumor-suppressor functions of p53 and the ASPP proteins. | aspp | tumor protein p53 | Homo sapiens |
| 4 | iASPP expression is upregulated in human breast carcinomas expressing wild-type p53 and normal levels of ASPP. | aspp | tumor protein p53 | Homo sapiens |