Title : PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter.

Pub. Date : 2003 Jan 1

PMID : 12517803






1 Functional Relationships(s)
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1 Treatment of U87MG cells with LY294002, a PI3K inhibitor, or cotransfection with a vector expressing wild-type PTEN decreased VEGF promoter activity using reporters containing either 1.5 kb of the promoter or a fragment extending from -88 to +54 bp. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one vascular endothelial growth factor A Homo sapiens