Title : Metformin modulates insulin post-receptor signaling transduction in chronically insulin-treated Hep G2 cells.

Pub. Date : 2003 Jan

PMID : 12511230






2 Functional Relationships(s)
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1 Tyrosine phosphorylation of IR?, IRS1, and IRS2 was increased by 2.7 fold (P < 0.01), 6.8 fold (P < 0.01), and 2.3 fold (P <0.01) of chronically insulin-treated cells alone, respectively, after metformin 0.1 mmol/L was added. Metformin insulin receptor substrate 1 Homo sapiens
2 In contrast, metformin in pharmacological concentration (1-10 mmol/L) further inhibited tyrosine phosphorylation of IR?, IRS1, IRS2 and the interaction of PI3K with IRS. Metformin insulin receptor substrate 1 Homo sapiens