Title : Down-regulation of deoxycytidine kinase in human leukemic cell lines resistant to cladribine and clofarabine and increased ribonucleotide reductase activity contributes to fludarabine resistance.

Pub. Date : 2003 Jan 15

PMID : 12504799






3 Functional Relationships(s)
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1 The CdA and CAFdA resistant cell lines exhibited increased resistance to the other nucleoside analogues activated by dCK. Clofarabine Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster
2 The CdA and CAFdA resistant cells displayed a deficiency in dCK activity (to <5%) while the Fara-A resistant cells showed only a minor reduction of dCK activity (20% reduction). Clofarabine Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster
3 We conclude that down-regulation of dCK in cells resistant to CdA and CAFdA and increased activity of RR in cells resistant to Fara-A contribute to resistance. Clofarabine Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster