Pub. Date : 2003 Jan 15
PMID : 12504799
3 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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1 | The CdA and CAFdA resistant cell lines exhibited increased resistance to the other nucleoside analogues activated by dCK. | Clofarabine | Calcium/calmodulin-dependent protein kinase II | Drosophila melanogaster | ||
2 | The CdA and CAFdA resistant cells displayed a deficiency in dCK activity (to <5%) while the Fara-A resistant cells showed only a minor reduction of dCK activity (20% reduction). | Clofarabine | Calcium/calmodulin-dependent protein kinase II | Drosophila melanogaster | ||
3 | We conclude that down-regulation of dCK in cells resistant to CdA and CAFdA and increased activity of RR in cells resistant to Fara-A contribute to resistance. | Clofarabine | Calcium/calmodulin-dependent protein kinase II | Drosophila melanogaster |