Title : Characterization of the allosteric inhibition of a protein-protein interaction by mass spectrometry.

Pub. Date : 2003 Jan

PMID : 12504329






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Binding of hydantoins to the I domain of LFA-1 is observed by size exclusion chromatography/mass spectrometry (SEC/MS) and by direct electrospray ionization mass spectrometry (ESI/MS). Hydantoins integrin subunit alpha L Homo sapiens
2 A photoactive hydantoin analog specifically labels an amino acid residue of LFA-1 I domain. Hydantoins integrin subunit alpha L Homo sapiens
3 The results demonstrate specific, stoichiometric, reversible binding of the hydantoins to LFA-1. Hydantoins integrin subunit alpha L Homo sapiens