Title : Novel role for apolipoprotein E in the central nervous system. Modulation of sulfatide content.

Pub. Date : 2003 Mar 7

PMID : 12501252






4 Functional Relationships(s)
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1 There was, however, a marked effect of apoE on the sulfatide (ST) content in both the brain and CSF. Sulfoglycosphingolipids apolipoprotein E Mus musculus
2 The sulfatide mass in hippocampus and cortex of apoE knockout mice was found to be 61 and 114 mol% higher than wild-type mice counterparts at 12 months of age. Sulfoglycosphingolipids apolipoprotein E Mus musculus
3 Examination of potential sulfatide carrier(s) in human CSF demonstrated that sulfatides are specifically associated with apoE-containing high density lipoproteins, suggesting that sulfatide levels in the central nervous system (CNS) are likely to be directly modulated by the same metabolic pathways that regulate levels of apoE-containing CNS lipoproteins. Sulfoglycosphingolipids apolipoprotein E Mus musculus
4 Examination of potential sulfatide carrier(s) in human CSF demonstrated that sulfatides are specifically associated with apoE-containing high density lipoproteins, suggesting that sulfatide levels in the central nervous system (CNS) are likely to be directly modulated by the same metabolic pathways that regulate levels of apoE-containing CNS lipoproteins. Sulfoglycosphingolipids apolipoprotein E Mus musculus