Title : MAP kinase and beta-catenin signaling in HGF induced RPE migration.

Pub. Date : 2002 Dec 20

PMID : 12500177






5 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Tyrosine phosphorylation of the HGF receptor (HGFR or c-met) and beta-catenin was determined by immunoprecipitation and western blot analysis. Tyrosine MET proto-oncogene, receptor tyrosine kinase Homo sapiens
2 Tyrosine phosphorylation of the HGF receptor (HGFR or c-met) and beta-catenin was determined by immunoprecipitation and western blot analysis. Tyrosine MET proto-oncogene, receptor tyrosine kinase Homo sapiens
3 Tyrosine phosphorylation of the HGF receptor (HGFR or c-met) and beta-catenin was determined by immunoprecipitation and western blot analysis. Tyrosine MET proto-oncogene, receptor tyrosine kinase Homo sapiens
4 HGF induced a MAP kinase dependent ARPE-19 cell migration, which is accompanied with a transient increase of c-jun expression and concomitant increases of MAP kinase activity, tyrosine phosphorylation of HGFR and beta-catenin, increased cytosolic levels of beta-catenin, and transactivation activity of beta-catenin. Tyrosine MET proto-oncogene, receptor tyrosine kinase Homo sapiens
5 Tyrosine phosphorylation of HGFR and beta-catenin occurs in the primary or passaged RPE cultures or proliferative ARPE-19 cells, but not freshly isolated RPE or differentiated ARPE-19 cells. Tyrosine MET proto-oncogene, receptor tyrosine kinase Homo sapiens