Title : Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide.

Pub. Date : 2002 Nov

PMID : 12495560






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The administration of ranitidine and nizatidine caused significant increases in plasma CGRP and SP levels at 30 to 120 min compared with the placebo group. Ranitidine tachykinin precursor 1 Homo sapiens
2 Maximum plasma SP levels (21.3+/-5.2 and 22.8+/-4.2 pg mL(-1)) were reached 60 min after administration of ranitidine and nizatidine, respectively. Ranitidine tachykinin precursor 1 Homo sapiens
3 The released CGRP and SP by ranitidine and nizatidine administration may produce a gastroprotective effect, increase mucosal blood flow, and inhibit acid secretion in the gastrointestinal tract. Ranitidine tachykinin precursor 1 Homo sapiens