Title : Pressor effects of L-glutamate injected into the diagonal band of Broca of unanesthetized rats.

Pub. Date : 2003 Jan 10

PMID : 12493620






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1 The pressor response to L-glutamate (30 nmol/200 nl) into the dbB was blocked by intravenous pretreatment with the vasopressin antagonist dTyr(CH(2))(5)(Me)AVP (50 microg/kg), suggesting the involvement of circulating vasopressin in this response. Glutamic Acid arginine vasopressin Rattus norvegicus
2 The pressor response to L-glutamate (30 nmol/200 nl) into the dbB was blocked by intravenous pretreatment with the vasopressin antagonist dTyr(CH(2))(5)(Me)AVP (50 microg/kg), suggesting the involvement of circulating vasopressin in this response. Glutamic Acid arginine vasopressin Rattus norvegicus
3 Further evidence of the involvement of the endocrine vasopressin system in the pressor response to L-glutamate injected into the dbB was provided by hypophysectomy since L-glutamate (30 nmol/200 nl) microinjection into the dbB of hypophysectomized rats caused only depressor responses. Glutamic Acid arginine vasopressin Rattus norvegicus
4 Further evidence of the involvement of the endocrine vasopressin system in the pressor response to L-glutamate injected into the dbB was provided by hypophysectomy since L-glutamate (30 nmol/200 nl) microinjection into the dbB of hypophysectomized rats caused only depressor responses. Glutamic Acid arginine vasopressin Rattus norvegicus
5 We presently report that chemical stimulation of the dbB with L-glutamate caused only pressor responses in unanesthetized rats that were mediated by vasopressin release into the systemic circulation. Glutamic Acid arginine vasopressin Rattus norvegicus