Title : Mechanism-based inactivation of cytochromes P450 2E1 and 2E1 T303A by tert-butyl acetylenes: characterization of reactive intermediate adducts to the heme and apoprotein.

Pub. Date : 2002 Dec

PMID : 12482238






1 Functional Relationships(s)
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1 The kinetics for the inactivation of cytochrome P450 2E1 and the mutant P450 2E1 T303A by tert-butyl acetylene (tBA) and tert-butyl 1-methyl-2-propynyl ether (tBMP) were investigated. tba cytochrome P450 2E1 Oryctolagus cuniculus