Title : Differential activation of AP-1 in human bladder epithelial cells by inorganic and methylated arsenicals.

Pub. Date : 2003 Jan

PMID : 12475910






2 Functional Relationships(s)
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1 In this study, we show that short-time exposures to 0.1-5 microM arsenite (iAsIII) or the methylated trivalent arsenicals methylarsine oxide (MAsIIIO), or iododimethylarsine (DMAsIIII) induce phosphorylation of c-Jun and increase AP-1 DNA binding activity in human bladder epithelial cells. arsenite Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 In this study, we show that short-time exposures to 0.1-5 microM arsenite (iAsIII) or the methylated trivalent arsenicals methylarsine oxide (MAsIIIO), or iododimethylarsine (DMAsIIII) induce phosphorylation of c-Jun and increase AP-1 DNA binding activity in human bladder epithelial cells. arsenite Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens