Pub. Date : 2002 Oct
PMID : 12475182
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Opposite actions of testosterone and progesterone on UCP1 mRNA expression in cultured brown adipocytes. | Testosterone | uncoupling protein 1 | Homo sapiens |
| 2 | In the present work, we aimed to investigate the effects of the main physiological male and female sex hormones, i.e. testosterone, progesterone and 17-beta-estradiol, on the expression of uncoupling protein I (UCP1)--the main mediator of BAT thermogenesis--and on UCP2 and lipid accumulation in rodent brown adipocytes differentiated in culture. | Testosterone | uncoupling protein 1 | Homo sapiens |
| 3 | Testosterone-treated cells showed fewer and smaller lipid droplets than control cells and a dose-dependent inhibition of UCP1 mRNA expression, under adrenergic stimulation by norepinephrine (NE). | Testosterone | uncoupling protein 1 | Homo sapiens |
| 4 | Thus, are conclude that testosterone, 17-beta-estradiol, progesterone and RU486 have distinct actions on brown adipocytes, thus modulating UCP1 and UCP2 mRNA expression and/or lipid accumulation, and that sex hormones are factors that may explain in part the gender-dependent BAT thermogenic response. | Testosterone | uncoupling protein 1 | Homo sapiens |