Title : Dissociation of GDP dissociation inhibitor and membrane translocation are required for efficient activation of Rac by the Dbl homology-pleckstrin homology region of Tiam.

Pub. Date : 2003 Feb 14

PMID : 12471028






1 Functional Relationships(s)
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1 Taken together, these experiments demonstrate that the dissociation of Rac-GDP from GDI and its translocation to membrane lipids favor DH-PH-catalyzed nucleotide exchange because the steric hindrance caused by GDI is relieved and because the membrane environment favors functional interaction between the DH-PH domain and the small G protein. Dihydrotestosterone AKT serine/threonine kinase 1 Homo sapiens