Title : Failure to increase glucose consumption through the pentose-phosphate pathway results in the death of glucose-6-phosphate dehydrogenase gene-deleted mouse embryonic stem cells subjected to oxidative stress.

Pub. Date : 2003 Mar 15

PMID : 12466018






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 G6PD has been generally considered essential for providing NADPH-reducing power. NADP glucose-6-phosphate dehydrogenase 2 Mus musculus
2 We now find that other reactions provide the cell with a large fraction of NADPH under non-stress conditions, whereas G6PD is the only NADPH-producing enzyme activated in response to oxidative stress, which can act as a guardian of the cell redox potential. NADP glucose-6-phosphate dehydrogenase 2 Mus musculus