Title : Effect of stathmin on the sensitivity to antimicrotubule drugs in human breast cancer.

Pub. Date : 2002 Dec 1

PMID : 12460900






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Overexpression of stathmin decreased polymerization of microtubules, markedly decreased binding of paclitaxel, and increased binding of vinblastine. Vinblastine stathmin 1 Homo sapiens
2 Stathmin overexpression decreased sensitivity to paclitaxel and, to a lesser extent, to vinblastine. Vinblastine stathmin 1 Homo sapiens
3 This effect was magnified when stathmin-overexpressing cells were treated with vinblastine as measured by the detection of proteins phosphorylated in early mitosis. Vinblastine stathmin 1 Homo sapiens