Pub. Date : 2003 Jan
PMID : 12457721
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Flavopiridol, a cyclin dependent kinase (CDK) inhibitor, induces apoptosis by regulating Bcl-x in oral cancer cells. | alvocidib | BCL2 like 1 | Homo sapiens |
| 2 | While Bcl-2 and Bax expression did not change, Bcl-x(L) was down regulated and Bcl-xs was up-regulated after being exposed to flavopiridol. | alvocidib | BCL2 like 1 | Homo sapiens |
| 3 | Flavopiridol not only inhibits CDKs directly, but it also inhibits the CDKs activation pathway and activates the Bcl-x apoptotic pathway. | alvocidib | BCL2 like 1 | Homo sapiens |