Title : Assessing hepatitis B virus resistance in vitro and molecular mechanisms of nucleoside resistance.

Pub. Date : 2002

PMID : 12447726






1 Functional Relationships(s)
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1 Mutations are selected in HBV polymerase that can discriminate among the structural differences between lamivudine triphosphate and the natural substrate mimicked by lamivudine, dCTP, causing steric hindrance and reduced efficiency of incorporation of lamivudine but not the natural substrate. lamivudine triphosphate cut up Drosophila melanogaster