Title : Transmembrane domain I of the gamma-aminobutyric acid transporter GAT-1 plays a crucial role in the transition between cation leak and transport modes.

Pub. Date : 2003 Feb 7

PMID : 12446715






3 Functional Relationships(s)
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1 GAT-1 expressed in Xenopus laevis oocytes exhibits sodium-dependent GABA-induced inward currents reflecting electrogenic sodium-coupled transport. gamma-Aminobutyric Acid solute carrier family 6 (neurotransmitter transporter), member 1 S homeolog Xenopus laevis
2 In lithium-containing medium, GAT-1 mediates GABA-independent currents, the relationship of which to the physiological transport process is poorly understood. gamma-Aminobutyric Acid solute carrier family 6 (neurotransmitter transporter), member 1 S homeolog Xenopus laevis
3 Thus, transmembrane domain I of GAT-1 contains determinants controlling both sodium-coupled GABA flux and the cation leak pathway as well as the interconversion of these distinct modes. gamma-Aminobutyric Acid solute carrier family 6 (neurotransmitter transporter), member 1 S homeolog Xenopus laevis