Pub. Date : 2002 Dec
PMID : 12438517
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Yohimbine dimers exhibiting selectivity for the human alpha 2C-adrenoceptor subtype. | Yohimbine | adrenoceptor alpha 2C | Homo sapiens |
| 2 | Initial studies showed that yohimbine was about 4- and 15-fold more selective for the human alpha2C-adrenoceptor in comparison with the alpha2A- and alpha2B-adrenoceptors, respectively. | Yohimbine | adrenoceptor alpha 2C | Homo sapiens |
| 3 | These findings demonstrate that the addition of spacer linkages to bivalent yohimbine molecules provides a successful approach to the development of ligands that are potent and highly selective for the alpha2C-adrenoceptor. | Yohimbine | adrenoceptor alpha 2C | Homo sapiens |