Title : The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules.

Pub. Date : 2002 Dec

PMID : 12438515






3 Functional Relationships(s)
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1 In Xenopus oocytes, the inhibitory potency of several rOCT1/2 inhibitors was similar for amantadine compared to TEA uptake and supports amantadine transport by rOCT1 and rOCT2. Tetraethylammonium solute carrier family 22 member 1 Rattus norvegicus
2 In proximal tubules, procainamide, quinine, cyanine(863), choline, and guanidine in concentrations that inhibit rOCT1/2-mediated TEA or amantadine uptake in Xenopus oocytes exhibited no effect on amantadine uptake. Tetraethylammonium solute carrier family 22 member 1 Rattus norvegicus
3 TEA uptake by the basolateral membrane may be mediated mainly by rOCT1 and rOCT2, but these transporters may be in a different functional or regulatory state when expressed in cells or oocytes compared with expression in vivo. Tetraethylammonium solute carrier family 22 member 1 Rattus norvegicus