Title : Characterization of nicotine and cotinine N-glucuronidations in human liver microsomes.

Pub. Date : 2002 Dec

PMID : 12433823






1 Functional Relationships(s)
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1 Nicotine and cotinine N-glucuronidations in pooled human liver microsomes were competitively inhibited by bilirubin as a substrate for UGT1A1 (K(i) = 3.9 and 3.3 micro M), imipramine as a substrate for UGT1A4 (K(i) = 6.1 and 2.7 micro M), and propofol as a substrate for UGT1A9 (K(i) = 6.0 and 12.0 micro M). Bilirubin UDP glucuronosyltransferase family 1 member A4 Homo sapiens