Title : Superoxide anions mediate veratridine-induced cytochrome c release and caspase activity in bovine chromaffin cells.

Pub. Date : 2002 Dec

PMID : 12429571






3 Functional Relationships(s)
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1 Superoxide anions mediate veratridine-induced cytochrome c release and caspase activity in bovine chromaffin cells. Superoxides LOC104968582 Bos taurus
2 Exposure to veratridine (30 micro M, 1 h) produces cytochrome c release to the cytoplasm that seems to be mediated by superoxide anions and that is blocked by cyclosporin A (10 micro M), MnTBAP (10 nM), catalase (100 IU ml(-1)) and vitamin E (50 micro M). Superoxides LOC104968582 Bos taurus
3 In conclusion, superoxide anions seem to mediate veratridine-induced cytochrome c release, decrease in total glutathione, caspase activation and cell death in bovine chromaffin cells. Superoxides LOC104968582 Bos taurus