Title : Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells.

Pub. Date : 2002 Nov 1

PMID : 12414639






1 Functional Relationships(s)
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1 Furthermore, treatment of mice bearing the PTEN-negative PC-3 prostate cancer xenografts with CCI-779, an ester of rapamycin in clinical development combined with doxorubicin, inhibited the growth of the doxorubicin-resistant PC-3 tumors confirming the observations in vitro. Sirolimus phosphatase and tensin homolog Mus musculus