Title : Glucuronidation of olanzapine by cDNA-expressed human UDP-glucuronosyltransferases and human liver microsomes.

Pub. Date : 2002 Jul

PMID : 12404680






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Only UGT1A4 was able to glucuronidate olanzapine obeying saturation kinetics. Olanzapine UDP glucuronosyltransferase family 1 member A4 Homo sapiens
2 The olanzapine glucuronidation reaction was inhibited by several drugs known as substrates for UGT1A4, e.g. amitriptyline, trifluoperazine and lamotrigine. Olanzapine UDP glucuronosyltransferase family 1 member A4 Homo sapiens