Title : Negative regulation of phosphatidylinositol 3-kinase and Akt signalling pathway by PKC.

Pub. Date : 2003 Jan

PMID : 12401518






1 Functional Relationships(s)
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1 In this study, we found that in A549 and HEK293 cells non-selective PKC inhibitors Ro 31-8220 and bisindolylmaleimide VIII, and PKCbeta inhibitor LY 379196, caused Akt/PKB phosphorylation at Ser 473 and increased the upstream activator, integrin-linked kinase (ILK) activity. bisindolylmaleimide protein kinase C beta Homo sapiens