Pub. Date : 2002 Oct 31
PMID : 12400005
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PKC activation induces the intracellular movement and co-localization of RACK1 and Src, and the tyrosine phosphorylation of RACK1. | Tyrosine | receptor for activated C kinase 1 | Homo sapiens |
| 2 | Moreover, Src activity is necessary for both the tyrosine phosphorylation of RACK1 and the binding of RACK1 to Src"s SH2 domain that occur following PKC activation. | Tyrosine | receptor for activated C kinase 1 | Homo sapiens |
| 3 | Moreover, Src activity is necessary for both the tyrosine phosphorylation of RACK1 and the binding of RACK1 to Src"s SH2 domain that occur following PKC activation. | Tyrosine | receptor for activated C kinase 1 | Homo sapiens |
| 4 | To identify the tyrosine(s) on RACK1 that is phosphorylated by Src, we generated and tested a series of RACK1 mutants. | Tyrosine | receptor for activated C kinase 1 | Homo sapiens |
| 5 | We found that Src phosphorylates RACK1 on Tyr 228 and/or Tyr 246, highly-conserved tyrosines located in the sixth WD repeat that interact with Src"s SH2 domain. | Tyrosine | receptor for activated C kinase 1 | Homo sapiens |
| 6 | We found that Src phosphorylates RACK1 on Tyr 228 and/or Tyr 246, highly-conserved tyrosines located in the sixth WD repeat that interact with Src"s SH2 domain. | Tyrosine | receptor for activated C kinase 1 | Homo sapiens |